Antiplatelet Aggregation Plants

Antiplatelet aggregating activity of extracts of ...

The present study was undertaken to screen the laxative and anthelmintic activity of Cassia alata flowers. The laxative activity was performed at a dose of 100 mg/kg and 200 mg/kg according to ...

A New Antiplatelet Diarylheptanoid from Alpinia ...

A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (1), along with seven other known compounds, were isolated from the seeds of Alpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood.

antiplatelet aggregation plants - greenrevolution.org.in

Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa204 Кб. Both compounds 1 and 2 are active in the antiplatelet aggregation assay.Plant Material Fresh leaves of M. omphalocarpa were collected from Pingtung County, Taiwan, in September 1999, and...

A novel anti-platelet aggregation target of ...

The platelet aggregation-related genes were found in databases, and antiplatelet aggregation-related gene targets were selected through comparison. The functions of target genes and related pathways were analysed and screened using the DAVID database, and the network of antiplatelet aggregation effect of isolated compounds was constructed using ...

(PDF) Antiplatelet aggregation and cytotoxic activity of ...

Jun 10, 2015· Antiplatelet aggregation and cytotoxic activity of betulinic acid and its acetyl derivative from Melaleuca bracteata Article (PDF Available) in Journal of medicinal plant …

Antiplatelet activity of white and pink Nelumbo nucifera ...

Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers 581 CaCl2 at a final concentration of 2μM. Platelet aggregation was recorded by increasing transmittance value of spec-trophotometric measurements. To determine the in vitro antiplatelet aggregation property, different concentrations

Frontiers | A Novel Antiplatelet Aggregation Target of ...

Jun 14, 2019· And the platelet aggregation-related genes were discovered in databases, and antiplatelet aggregation-related gene targets were selected through comparison. The functions of target genes and related pathways were analyzed and screened using the DAVID database, and the network was constructed using Cytoscape software.

Coumarins and antiplatelet aggregation constituents from ...

The structure of new compound 3 thus was elucidated as ( +__ )-cis-4'-tigloylkhellactone. Compound 4, [~t]2D6: + 254(CHC13, c0.14), was iso- lated as prisms and the molecular formula was estab- lished as C19H2006 by E1 and HR mass spectrometry Coumarins and Antiplatelet Aggregation constituents from Formosan Peucedanum japonicum 527 Table 1.

(PDF) Plant Alkaloids as Antiplatelet Agent: Drugs of the ...

Plant Alkaloids as Antiplatelet Agent: Drugs of the Future in the Light of Recent Developments Article (PDF Available) in Frontiers in Pharmacology 7(28) · September 2016 with 318 Reads

A Review of Antiplatelet Activity of Traditional Medicinal ...

Thrombotic events mainly occurred by platelet activation and aggregation. The vascular occlusion causes serious disease states such as unstable angina, ischemic stroke, and heart attack. Due to the pervading of thrombotic diseases, new antiplatelet drugs are necessary for preventing and treating arterial thrombosis without adverse side effects.

(PDF) Effect of Isoquinoline Alkaloids of Different ...

Effect of Isoquinoline Alkaloids of Different Structural Types on Antiplatelet Aggregation in Vitro Yi-Chen Chia1, Fang-Rong Chang2, Chin-Chung Wu2, Che-Ming Teng3, Keh-Shaw Chen1, Yang-Chang Wu2 Abstract Forty-one isoquinoline alkaloids were tested for antiplatelet ag- gregation effects.

Antiplatelet and Vasorelaxing Actions of Some ...

Members of a series of benzylisoquinoline and phenanthrene alkaloids were tested for their antiplatelet and vasorelaxing actions. Atherosperminine HClO4 (15) and atherosperminium I (16) showed strong inhibition of adenosine 5‘-diphosphate-induced platelet aggregation. dl-N-Methylcoclaurine (1), dl-coclaurine (6), 15, 16, xylopine hydroxylamine (18), and …

Antiplatelet aggregation activity of diterpene alkaloids ...

Aug 02, 2002· 3.3. Comparison of in vitro antiplatelet activities of atisine-type alkaloids with those of ginkgolide B and aspirin. A comparison of the inhibitory effects of atisine-type alkaloids, ginkgolide B and aspirin on PAF, arachidonic acid and ADP-induced platelet aggregation is shown in Table 1.Of the 14 test compounds, 12 selectively inhibited platelet aggregation induced by PAF.

(PDF) PHYTOCHEMICAL SCREENING AND IN-VITRO ANTI-PLATELET ...

The objective of the present study is to evaluate the anti-platelet aggregation activity of saraca indica. Standard methods were adopted for evaluation of In-vitro anti-platelet aggregation ...

Antiplatelet aggregation triterpene saponins from the ...

Thus, in order to search new bioactive antiplatelet aggregation triterpene saponins, we carried out a phytochemical investigation on the leaves of I. kudingcha. The isolation and structure elucidation of two new ursane-type triterpene saponins (1 and 2), along with …

Medicinal Herbals with Antiplatelet Properties Benefit in ...

Medicinal Herbals with Antiplatelet Properties Benefit in Coronary Atherothrombotic Diseases. ... There are a lot of plants that exhibit antiplatelet properties. ... “Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation,” Thrombosis Research, vol. 103, no. 5, ...

Medicinal Herbals with Antiplatelet Properties Benefit in ...

Mar 14, 2016· Coronary atherothrombotic diseases such as coronary artery disease, peripheral vascular disease, cerebrovascular disease, and heart failure are the serious concerns of the thrombus formed in blood vessels. Anticoagulant and antiplatelet drugs are the …

Evaluation of Anti-Platelet Aggregation Effect of Some ...

Anti-platelet aggregation activity is not uncommon from plants extracts. Gady’s et al (2009) have reported a significant platelet aggregation inhibitory activity from the total aqueous extract of leaves of parsley (IC 50: 5.6mg/ml) against the aggregation induced by ADP .

Triterpenoids with antiplatelet aggregation activity from ...

The antiplatelet aggregation of all compounds were evaluated against ADP induced rat platelet aggregation in vitro, and five compounds exhibited moderate inhibitory effects with IC 50 values ranging from 22.4 to 32.8 μM.

Plant Alkaloids as Antiplatelet Agent: Drugs of the Future ...

Sep 22, 2016· Antiplatelet mechanism of plant alkaloids. Various mechanisms have been proposed for the antiplatelet activity of different isolated plant-alkaloids (Figure (Figure1). 1).Researchers have proposed that berberine significantly inhibited platelet aggregation by inhibiting synthesis of thromboxane A2 induced by adenine diphosphate, arachidonic acid, collagen (Chu et al., 1996).

Antiplatelet Aggregation Activity of Walnut Hull Extract ...

In this equation, APA is the percentage of antiplatelet aggregation, A T is the absorbance at the end of reaction for the test sample (extract- and thrombin-treated cells), and A C is the absorbance at the end of reaction for control sample (thrombin-treated cells). 2.11. …

In Vitro Platelet Aggregation Inhibition Activity of ...

the percent antiplatelet activity with the succeeding formula: % Inhibition of Platelet Aggregation = The percent inhibition of platelet aggregation values compares the absorbance readings among treated (with plant extract or aspirin) controls and the untreated control. Percent Antiplatelet Activity

An Overview of Medicinal Plants as Potential Anti-Platelet ...

An Overview of Medicinal Plants as Potential Anti-Platelet Agents Mridul Bhowal1, Darshika M Mehta2 1B Pharm, PES College of Pharmacy, 50 feet road, Hanumanthanagar, ... Chang FR, Wei JL, Teng CM, and Wu YC, Antiplatelet aggregation constituents from Annona purpurea, J Nat Prod, 61(12), 1998, 1457-61.

Antiplatelet Aggregation Coumarins from the Leaves of ...

antiplatelet aggregation induced by arachidonic acid (AA) and collagen [4]. In the continuing phytochemical investigation, two coumarins, minumicroline acetonide (1) [5-6] and epimurpaniculol senecioate (2), were isolated from the methanoic extracts of the leaves of this plant by the way of bioactivity-guided fractionation method.

ANTIPLATELET AYURVEDIC HERBS IN THE MANAGEMENT …

ANTIPLATELET AYURVEDIC HERBS IN THE MANAGEMENT OF CARDI-OVASCULAR DISEASE-A REVIEW Vidhya Unnikrishnan1, Nishteswar K 2 1 PhD scholar, 2 Professor& Head, Department of Dravyaguna, I.P.G.T&R.A, GAU, Jamnagar, Gujarat, India INTRODUCTION Cardiovascular disease (C VD), in-cluding heart disease and stroke, is the

Frontiers | Plant Alkaloids as Antiplatelet Agent: Drugs ...

The commonly used antiplatelet, aspirin, originated from salicin obtained from willow plant commonly used in pain medication. This review describes various alkaloids isolated from plant sources having antiplatelet activity with possible mechanisms and candidates for further detailed studies in the drug discovery as antiplatelet agents.

antiplatelet aggregation plants-[mining plant]

Antiplatelet activity of white and pink Nelumbo nucifera Gaertn .... antiplatelet aggregation property, different concentrations (100, 200, 300, 400 and 500µg/ml) of plant extract were added to the platelet suspension for 1min exposure …

List of Platelet aggregation inhibitors - Drugs.com

Platelet aggregation inhibitors work in different places of the clotting cascade and prevent platelet adhesion, therefore no clot formation. Aspirin, the most commonly used antiplatelet drug changes the balance between prostacyclin (which inhibits platelet aggregation) and thromboxane (that promotes aggregation).

PlantAlkaloidsasAntiplateletAgent ...

Pervaiz A (2016) Plant Alkaloids as Antiplatelet Agent: Drugs of the Future in the Light of Recent Developments. ... Similarly, platelet aggregation beyond the purpose of homeostasis is